Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | C7 |
| Chromosome | 5p13.1 |
| Function | The primary function of C7 is in the terminal pathway of the complement system. |
| Amino Acids | 809 aa |
| Ensembl ID | ENSG00000124429 |
| GeneCards | C7 |
| Human Protein Atlas | C7 |
| Amyotrophic Lateral Sclerosis (ALS) | Complement activation is observed in ALS motor cortex and spinal cord |
| Frontotemporal Dementia | MAC deposition found in FTD brain tissue |
| Huntington's Disease | Complement proteins upregulated in HD brain |
| Liver | Primary site of complement protein synthesis |
| Brain | Expressed by astrocytes and microglia, particularly under inflammatory conditions |
| Kidney | Local synthesis in glomerular cells |
| Lung | Expression in alveolar epithelial cells |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
C7["C7"]
neurodegeneration["neurodegeneration"]
C7 -->|"implicated_in"| neurodegeneration
style C7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SLC7A11 System Activation Restores Cystine Uptake and GSH Sy | 0.812 | neurodegeneration | View |
| Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Ce | 0.620 | - | Ferroptosis in ALS and motor neuron dise |
| EP4 Receptor Agonism for SLC7A11 Upregulation | 0.550 | neurodegeneration | Can ferroptosis inhibitors prevent BBB d |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Gandouling protection against brain injury in Wilson's disease via SIR | validation | Hepatolenticular degeneration | 0.900 | 0.00 | TX mice (Wilson's disease mode | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning C7 in their description or question text
No additional research found