gene 1,768 words KG: SLC7A2
Contents

SLC7A2 — Solute Carrier Family 7 Member 2 ( cationic amino acid transporter 2)

🧬 Gene Info
Gene SymbolSLC7A2
Full NameSolute Carrier Family 7 Member 2
Aliases cationic amino acid transporter 2
Chromosome8p22
Functionis a membrane protein that mediates the transport of cationic amino acids across cell membranes[@closs1996].
Primary Expressionneurons, astrocytes, microglia, and endothelial cells of the blood-brain barrier[@bertz2014] - Kidney: High expression in renal tubular cells[@sil
Molecular Weight70 kDa
Amino Acids630 aa
PathwaysInteraction
GeneCardsSLC7A2
Human Protein AtlasSLC7A2
BrainExpressed in neurons, astrocytes, microglia, and endothelial cells of the blood-brain barrier[@bertz2014]
KidneyHigh expression in renal tubular cells[@silbernagl2003]
LiverModerate expression in hepatocytes
LungDetected in alveolar epithelial cells
Associated Diseasesneurodegeneration
InteractionsMTORC1
KG Connections6 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

APOE-Dependent Autophagy Restoration
Score: 0.88
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75

Related Analyses (3)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (3)

Neurodegeneration
disease · KG edge: implicated_in
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
Packard Center for ALS Research
institution · KG edge: inhibits

Knowledge Graph (6 edges)

genes-slc7a2 linked_to SLC7A2
SLC7A2 activates MTORC1
SLC7A2 activates Diabetes
SLC7A2 inhibits Als
SLC7A2 activates Mtor
SLC7A2 activates Cell Cycle

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.