Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| h-6aebb76ee3 | targeted_by | hypothesis | 1.00 |
| mitophagy | activates | process | 0.70 |
| Alzheimer's disease | associated_with_microglial_priming | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-6aebb76ee3 | targets | hypothesis | 1.00 |
| H1 | associated_with | hypothesis | 0.50 |
| h-48775971 | targets | hypothesis | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biase | 0.670 | neurodegeneration | Do SCFAs directly modulate α-synuclein a |
| Physiological SCFAs may worsen alpha-synuclein pathology thr | 0.550 | neurodegeneration | Do physiological concentrations of SCFAs |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651
neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.82 · 2026-04-22
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
Hypotheses and analyses mentioning GPR43 in their description or question text
No additional research found