gene

BBC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BBC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

8Outgoing

3Incoming

0Experiments

0Debates

Summary

BBC3 (PUMA) encodes a pro-apoptotic BH3-only protein, a critical mediator of p53-dependent apoptosis in neurodegeneration.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	BBC3
Full Name	BCL2 Binding Component 3 (PUMA)
Aliases	BBC3 gene encoding PUMA
Chromosome	19q13.32
Function	Unlike anti-apoptotic Bcl-2 proteins or pro-apoptotic Bax/Bak proteins, BH3-only proteins contain only the BH3 (Bcl-2 Homology 3) domain, which is essential for their pro-apoptotic function.
Amino Acids	193 aa
UniProt ID	[Q9BXW1](https://www.uniprot.org/uniprotkb/Q9BXW1/entry)
Ensembl ID	ENSG00000100711
GeneCards	BBC3
Human Protein Atlas	BBC3
PUMA-α	Full-length protein with mitochondrial localization
PUMA-β	Alternatively spliced variant with distinct N-terminus
Direct activation	Can directly activate Bax/Bak to trigger mitochondrial outer membrane permeabilization (MOMP)
Sensitization	Can displace activators from anti-apoptotic Bcl-2 proteins
Binding	Interacts with all anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL, Mcl-1, etc.)
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ATP
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BBC3

gene · 1816 words

→

BBC3 — BCL2 Binding Component 3 (PUMA)

gene · 2006 words

→

Pathway Diagram

graph TD
    BBC3["BBC3"]
    Tumor{"Tumor"}
    BBC3 -->|"expressed_in"| Tumor
    Cancer{"Cancer"}
    BBC3 -->|"expressed_in"| Cancer
    CDKN1A["CDKN1A"]
    BBC3 -->|"expressed_in"| CDKN1A
    GENES["GENES"]
    BBC3 -->|"expressed_in"| GENES
    CANCER["CANCER"]
    BBC3 -->|"expressed_in"| CANCER
    ATP["ATP"]
    BBC3 -->|"inhibits"| ATP
    Mitochondrial_Function(["Mitochondrial Function"])
    BBC3 -->|"inhibits"| Mitochondrial_Function
    Lipid_Metabolism(["Lipid Metabolism"])
    BBC3 -->|"inhibits"| Lipid_Metabolism
    BAX["BAX"]
    BAX -->|"expressed_in"| BBC3
    BRCA1["BRCA1"]
    BRCA1 -->|"expressed_in"| BBC3
    P53["P53"]
    P53 -->|"expressed_in"| BBC3
    neurodegeneration["neurodegeneration"]
    BBC3 -->|"implicated_in"| neurodegeneration

Outgoing (8)

Target	Relation	Type	Str
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
ATP	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60
Mitochondrial Function	inhibits	pathway	0.60
CANCER	expressed_in	gene	0.60
CDKN1A	expressed_in	gene	0.60

Incoming (3)

Source	Relation	Type	Str
P53	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
BRCA1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BBC3 in their description or question text

No additional research found