protein

AURKBPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AURKBPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

AURKB is a catalytic subunit of the Chromosomal Passenger Complex (CPC), which also contains INCENP, Survivin (BIRC5), and Borealin (CDCA8).

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🔬 Protein Info

Gene Symbol	AURKBPROTEIN
Chromosome	17p13.1
Protein Type	Serine/Threonine Kinase
Function	is a chromosomal passenger protein and serine/threonine kinase that plays critical roles in mitosis, cytokinesis, and regulation of histone modifications.
Primary Expression	post-mitotic neurons where it performs distinct functions
Subcellular Localization	** \| Centromere, midbody, nucleus \|
Molecular Weight	39 kDa
GeneCards	AURKBPROTEIN
Human Protein Atlas	AURKBPROTEIN
Histone H3	Serine 10 phosphorylation promotes chromatin condensation
INCENP	Autophosphorylation enhances CPC activity
MgcRacGAP	Regulation of Rho GTPases during cytokinesis
Kinetochore proteins	MLKN1, CENP-A, borealin for proper kinetochore function
Synaptic vesicle trafficking	Regulates presynaptic vesicle dynamics
Dendritic spine morphology	Controls spine formation and maintenance
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AMPK, ASPM, ATG, CALM1, CANCER
KG Connections	85 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

aurkb-protein

protein · 1685 words

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Pathway Diagram

graph TD
    AURKBPROTEIN["AURKBPROTEIN"]
    neurodegeneration["neurodegeneration"]
    AURKBPROTEIN -->|"implicated_in"| neurodegeneration
    style AURKBPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning AURKBPROTEIN in their description or question text

No additional research found