gene

atg4a

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about atg4a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

9Outgoing

9Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ATG4A
Chromosome	Xq22.1
Protein Type	Protease
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various tissues with high expression in:
Molecular Weight	44 kDa
Amino Acids	393 aa
Exons	14
Pathways	mTOR, mtor
GeneCards	ATG4A
Human Protein Atlas	ATG4A
Associated Diseases	Neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATG4A Gene

gene · 773 words

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Pathway Diagram

flowchart TD
    N0["ATG4A"]
    N1["Ms"]
    N0 -->|"activates"| N1
    N2["MAP1LC3B2"]
    N0 -->|"causes"| N2
    N3["AUTOPHAGY"]
    N0 -->|"activates"| N3
    N4["Autophagy"]
    N0 -->|"activates"| N4
    N5["NEURODEGENERATIVE DISORDERS"]
    N5 -->|"activates"| N0
    N6["VIRAL INFECTIONS"]
    N6 -->|"activates"| N0
    N7["ATG7"]
    N7 -->|"causes"| N0
    N8["AND"]
    N8 -->|"causes"| N0
    N9["GENES"]
    N9 -->|"activates"| N0
    N10["TBK1"]
    N10 -->|"causes"| N0
    N11["neurodegeneration"]
    N0 -->|"implicated in"| N11

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 pathway
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene

Outgoing (9)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG4A	data_in	dataset_row	0.00
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
ATG4D	associated_with	gene	0.60
MAP1LC3B2	causes	gene	0.60
Autophagy	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
ATG4C	associated_with	gene	0.60
ATG4B	associated_with	gene	0.60

Incoming (9)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG4A	data_in	dataset_row	0.00
ATG7	causes	gene	0.60
TBK1	causes	gene	0.60
ATG4D	associated_with	gene	0.60
ATG4B	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
AND	causes	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning atg4a in their description or question text

No additional research found