ARK

The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

The debate revealed a critical gap: while excitatory neurons show mitochondrial

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

p16^INK4a-CCF Axis as Senolytic Timing Biomarker

Score: 0.755 · molecular biology · 2026-04-21

**Molecular Mechanism and Rationale** The p16^INK4a-CCF axis represents a sophisticated temporal biomarker system that

SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy D

Score: 0.738 · Alzheimer's Disease · 2026-04-02

## Mechanistic Overview SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy Dysfunction start

Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Anta

Score: 0.735 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Antagonist in Tau Ph

CSF YKL-40 as a Priming-Specific Chitinase Marker

Score: 0.714 · biomarkers · 2026-04-22

## Mechanistic Overview CSF YKL-40 as a Priming-Specific Chitinase Marker starts from the claim that modulating CHI3L1/Y

Creatine Kinase System Capacity as Neural Energy Reserve Biomarker

Score: 0.707 · translational neuroscience · 2026-04-16

## Mechanistic Overview Creatine Kinase System Capacity as Neural Energy Reserve Biomarker starts from the claim that mo

CSF/Plasma AQP4 Polarization Index as a Novel Biomarker of Astrocyte Glymphatic

Score: 0.705 · unknown disease · 2026-04-26

Aquaporin-4 (AQP4) water channels are normally concentrated at astrocyte end-feet ensheathing cerebral microvessels. Ear

Pericyte-targeted senolysis or senomorphic therapy will benefit only an early bi

Score: 0.700 · neurodegeneration · 2026-04-25

Therapeutic benefit from pericyte-directed senescence interventions depends on stage. If BBB leak and dysfunction occur

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

Score: 0.699 · neuroscience · 2026-04-26

FRAP-based measurement of TDP-43 liquid-liquid phase separation state provides a continuous biomarker of nuclear-cytopla

mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker

Score: 0.682 · molecular biology · 2026-04-21

## Mechanistic Overview mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker starts from the claim that m

Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker

Score: 0.677 · translational neuroscience · 2026-04-16

## Mechanistic Overview Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker starts from the claim tha

OPTN/TBK1 mutations create selective vulnerability by blocking PINK1-Parkin-inde

Score: 0.670 · neurodegeneration · 2026-04-21

## Mechanistic Overview OPTN/TBK1 mutations create selective vulnerability by blocking PINK1-Parkin-independent mitophag

Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-β as Sentinel Event

Score: 0.662 · unknown disease · 2026-04-26

CSF soluble PDGFR-β shedding from pericytes as the earliest detectable molecular event in AD, preceding amyloid/tau path

TREM2-Driven Senescence Biomarker Index for Predicting Neurodegeneration Risk

Score: 0.642 · neurodegeneration · 2026-04-20

**Molecular Mechanism and Rationale** The TREM2 (Triggering Receptor Expressed on Myeloid cells 2) pathway represents a

Circulating Endothelial Microvesicles Expressing Degraded Claudin-5 as Specific

Score: 0.640 · unknown disease · 2026-04-26

Endothelial cells shed microvesicles (EMVs) during activation or injury. EMVs from degenerating brain endothelium carry

Retromer-dependent retrograde endosomal signaling compartmentalization as biomar

Score: 0.620 · neuroscience · 2026-04-26

VPS26/VPS29/VPS35 retromer complex maintains axonal endosomal signaling microdomains controlling TrkB/p75NTR trafficking