gene

ap2a1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ap2a1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

7Outgoing

4Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	AP2A1
Aliases	Adaptor-Related Protein Complex 2 Alpha 1
Chromosome	19q13.33
Function	encodes a 977-amino acid protein that serves as the largest subunit of the AP-2 heterotetramer, which also includes beta-2, mu-2, and sigma-2 subunits.
Molecular Weight	130 kDa
Amino Acids	977 aa
Pathways	Autophagy, Endocytosis
Ensembl ID	ENSG00000146938
GeneCards	AP2A1
Human Protein Atlas	AP2A1
AP2A1 (α-adaptin)	The largest subunit, containing the core and ear domains
AP2B1 (β2-adaptin)	Shares structural similarity with AP2A1
N-terminal trunk	Forms the core of the complex, interacting with other AP-2 subunits
Linker region	Flexible region connecting trunk to ear
C-terminal ear (appendage)	Platform for protein-protein interactions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ap2a1

gene · 1154 words

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Pathway Diagram

flowchart TD
    N0["AP2A1"]
    N1["AP2M1"]
    N0 -->|"activates"| N1
    N2["AUTOPHAGY"]
    N0 -->|"activates"| N2
    N3["LC3"]
    N0 -->|"activates"| N3
    N4["Autophagy"]
    N0 -->|"activates"| N4
    N5["Endocytosis"]
    N0 -->|"activates"| N5
    N6["AND"]
    N6 -->|"activates"| N0
    N3 -->|"activates"| N0
    N7["neurodegeneration"]
    N0 -->|"implicated in"| N7

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 pathway
    class N5 pathway
    class N6 gene

Outgoing (7)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:AP2A1	data_in	dataset_row	0.00
ds-db4a006ea647	provides_data_for	dataset	1.00
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Endocytosis	activates	pathway	0.60
AP2M1	activates	gene	0.60
LC3	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:AP2A1	data_in	dataset_row	0.00
ds-db4a006ea647	data_in	dataset	1.00
LC3	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ap2a1 in their description or question text

No additional research found