entity

extracellular_vesicles

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about extracellular_vesicles: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

5Hypotheses

4Analyses

1Outgoing

2Incoming

0Experiments

4Debates

No AI portrait yet

Outgoing (1)

Target	Relation	Type	Str
Alzheimer's disease	biomarker_for	disease	0.70

Incoming (2)

Source	Relation	Type	Str
amyloid_beta	associated_with	protein	0.80
tau	associated_with	protein	0.75

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 3: HepaCAM-Containing Extracellular Vesicles	0.762	neurodegeneration	View
GFAP-Bearing Circulating Extracellular Vesicles Originating	0.640	-	What blood-brain barrier permeability ch
Blocking Tau Packaging into Small Extracellular Vesicles via	0.610	neuroscience	Trans-synaptic tau spreading and propaga
Ganglioside-rich extracellular vesicles preserve alpha-synuc	0.582	neurodegeneration	Which specific CSF molecular components
Tumor-derived extracellular vesicles as TREM2 ligands	0.490	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway

Mentioning Analyses (4)

Scientific analyses that reference this entity

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.532

Which tau propagation mechanism predominates in different brain regions and dise

neurodegeneration | 2026-04-07 | 6 hypotheses Top: 0.740

Trans-synaptic tau spreading and propagation mechanisms in AD

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.750

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Recent Developments in Diabetic Retinal Neurodegeneration: A Literature Review. [PMID:34151902]	Unknown	J Diabetes Res	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Infectious agents and neurodegeneration. [PMID:22899188]	De Chiara G, Marcocci ME, Sgarbanti R, C	Molecular neurobiology	2012
TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124]	Unknown	Prog Brain Res	2008

Debates (4)

Multi-agent debates referencing this entity

Tau pathology spreads through synaptically connected brain regions in Alzheimer

closed · Rounds: 4 · Score: 0.78 · 2026-04-22

The debate considered multiple propagation routes (synaptic, extracellular vesic

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

What are the mechanisms by which tau pathology spreads through connected brain r

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Which EV-derived biomarkers (phospho-tau, amyloid-beta, synaptic proteins, infla

closed · Rounds: 4 · Score: 0.75 · 2026-04-12

Related Research

Hypotheses and analyses mentioning extracellular_vesicles in their description or question text

No additional research found