concept

α-SYNUCLEIN AGGREGATION

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about α-SYNUCLEIN AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

1Analyses

20Outgoing

13Incoming

0Experiments

1Debates

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💡 Concept Info

Name	α-SYNUCLEIN AGGREGATION

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Alpha-Synuclein Aggregation in PD

mechanism · 1960 words

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Pathway Diagram

graph TD
    __SYNUCLEIN_AGGREGATION[α-SYNUCLEIN AGGREGATION]
    __SYNUCLEIN_AGGREGATION -->|contributes to| Neuronal_Death[Neuronal Death]
    __SYNUCLEIN_AGGREGATION -->|causes| dopaminergic_neuron_loss[dopaminergic neuron loss]
    __SYNUCLEIN_AGGREGATION -->|causes| Parkinson_s_Disease[Parkinson's Disease]
    __SYNUCLEIN_AGGREGATION -->|contributes to| Neurodegeneration[Neurodegeneration]
    __SYNUCLEIN_AGGREGATION -->|contributes to| Parkinson_s_disease[Parkinson's disease]
    __SYNUCLEIN_AGGREGATION -->|causes| Dementia_With_Lewy_Bodies[Dementia With Lewy Bodies]
    __SYNUCLEIN_AGGREGATION -->|causes| Multiple_System_Atrophy[Multiple System Atrophy]
    __SYNUCLEIN_AGGREGATION -->|activates| Oxidative_stress[Oxidative stress]
    __SYNUCLEIN_AGGREGATION -->|activates| CGAS_STING_pathway[CGAS-STING pathway]
    __SYNUCLEIN_AGGREGATION -->|causes| neurodegeneration[neurodegeneration]
    MT1[MT1] -->|inhibits| __SYNUCLEIN_AGGREGATION
    Glucosylceramide_Accumulation[Glucosylceramide Accumulation] -->|contributes to| __SYNUCLEIN_AGGREGATION
    GCase_inhibition[GCase inhibition] -->|exacerbates| __SYNUCLEIN_AGGREGATION
    RNA_G_quadruplexes[RNA G-quadruplexes] -->|promotes| __SYNUCLEIN_AGGREGATION
    O_GlcNAcase_inhibition[O-GlcNAcase inhibition] -->|inhibits| __SYNUCLEIN_AGGREGATION
    autophagy_lysosomal_pathway[autophagy-lysosomal pathway] -->|regulates| __SYNUCLEIN_AGGREGATION
    RNA_G_quadruplex[RNA G-quadruplex] -->|promotes| __SYNUCLEIN_AGGREGATION
    __synuclein[α-synuclein] -->|regulates| __SYNUCLEIN_AGGREGATION

Outgoing (20)

Target	Relation	Type	Str
Parkinson'S Disease	contributes_to	disease	0.95
dopaminergic neuron loss	causes	phenotype	0.90
Lewy body formation	associated_with	process	0.90
Parkinson's disease	associated_with	disease	0.90
Parkinson's Disease	causes	disease	0.90
Neurodegeneration	contributes_to	phenotype	0.90
Neuronal Death	contributes_to	process	0.90
Neurodegeneration	contributes_to	phenotype	0.90
Multiple System Atrophy	causes	disease	0.85
Dementia With Lewy Bodies	causes	disease	0.85
Oxidative stress	activates	process	0.85
Neuroinflammation	contributes_to	process	0.85
CGAS-STING pathway	activates	pathway	0.80
α-synuclein propagation	causes	cellular_process	0.78
Mitochondrial dysfunction	causes	cellular_mechanism	0.75
Neuroinflammation	causes	cellular_mechanism	0.72
neuronal death	promotes	process	0.70
dementia with Lewy bodies	associated_with	disease	0.70
neurodegeneration	causes	process	0.70
multiple system atrophy	associated_with	disease	0.70

Incoming (13)

Source	Relation	Type	Str
RNA G-quadruplex	associated_with	compound	0.95
MT1	inhibits	receptor	0.90
Glucosylceramide Accumulation	contributes_to	phenotype	0.88
GCase inhibition	exacerbates	mechanism	0.85
O-GlcNAcase inhibition	inhibits	mechanism	0.80
Lysosomal dysfunction	causes	cellular_mechanism	0.80
RNA G-quadruplexes	promotes	compound	0.80
Curli fibrils in brain	seeds	protein	0.70
Curli-producing E. coli	accelerates	bacteria	0.70
α-synuclein	regulates	protein	0.70
autophagy-lysosomal pathway	regulates	pathway	0.70
Oxidative stress	causes	cellular_mechanism	0.70
21325059	is considered the disease-causative mechanism of	paper	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

neurodegeneration | 2026-04-12 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

closed · Rounds: 4 · Score: 0.84 · 2026-04-12

Related Research

Hypotheses and analyses mentioning α-SYNUCLEIN AGGREGATION in their description or question text

No additional research found