Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lewy Body Formation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Lewy bodies (LBs) are cytoplasmic inclusions that represent one of the hallmark neuropathological features of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). First described by Friedrich Lewy in 1912, these spherical proteinaceous aggregates accumulate primarily within neurons and are
No AI portrait yet
| Name | Lewy Body Formation |
| Key Genes/Proteins | Alpha-Synuclein, SNCA |
Knowledge base pages for this entity
graph TD
Lewy_Body_Formation["Lewy Body Formation"]
Alpha_Synuclein(["Alpha-Synuclein"])
SNCA(["SNCA"])
SNCA_Transcription["SNCA Transcription"]
Alpha_Synuclein -->|"involved in"| Lewy_Body_Formation
SNCA -->|"involved in"| Lewy_Body_Formation
Alpha_Synuclein -->|"causes"| Lewy_Body_Formation
SNCA_Transcription -->|"regulates"| Lewy_Body_Formation
style Lewy_Body_Formation fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Alpha_Synuclein fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
style SNCA fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
style SNCA_Transcription fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SNCA | involved_in | protein | 0.95 |
| Alpha-Synuclein | involved_in | protein | 0.95 |
| α-synuclein aggregation | associated_with | process | 0.90 |
| Alpha-Synuclein | causes | protein | 0.90 |
| SNCA Transcription | regulates | process | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Lewy Body Formation in their description or question text
No additional research found