| Gene Symbol | SLC11A1 |
| Aliases | NRAMP1 |
| Chromosome | 2q35 |
| Protein Type | Transporter |
| Function | encodes a divalent metal transporter that plays critical roles in iron and manganese homeostasis, macrophage activation, and neuroinflammatory responses. |
| Primary Expression | microglia and peripheral macrophages, where it regulates intracellular metal concentrations and modulates inflammatory responses |
| Molecular Weight | 55 kDa |
| Amino Acids | 550 aa |
| Exons | 15 |
| Ensembl ID | ENSG00000008080 |
| GeneCards | SLC11A1 |
| Human Protein Atlas | SLC11A1 |
| N-terminal region | Intracellular loop containing targeting motifs |
| Transmembrane helices 1-10 | Form the transport channel |
| C-terminal region | Intracellular domain with regulatory functions |
| Associated Diseases | neurodegeneration |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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