| Gene Symbol | RAB5A |
| Full Name | Ras-Related Protein Rab-5A |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 24 kDa |
| Amino Acids | 218 aa |
| Pathways | MAPK signaling |
| Ensembl ID | ENSG00000108510 |
| GeneCards | RAB5A |
| Human Protein Atlas | RAB5A |
| GTPase-Activating Proteins (GAPs) | RabGAP5 and other GAPs accelerate GTP hydrolysis, returning RAB5A to its inactive state |
| Enlarged Early Endosomes | Observed in Down syndrome brain and familial AD cases, preceding other pathology |
| RAB5 Overactivity | Increased RAB5A expression and activity contributes to endosomal enlargement |
| Cargo Sorting Defects | Impaired trafficking of APP, BACE1, and Aβ-generating enzymes |
| Associated Diseases | Als |
| Interactions | NEURODEGENERATIVE DISEASES |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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