| Gene Symbol | WDR81 |
| Full Name | WD Repeat Domain 81 |
| Aliases | WDR81PROTEIN |
| Chromosome | 17p13.1 |
| Function | encodes a protein containing multiple WD repeat domains, which form beta-propeller structures that mediate protein-protein interactions. |
| Primary Expression | the brain, particularly in the cerebellum and cerebral cortex, where it plays crucial roles in neuronal development, synaptic function, and autophagy |
| Subcellular Localization | **C-terminal Domain**: Mediates interactions with cytoskeletal proteins and signaling molecules |
| Molecular Weight | 270 kDa |
| Amino Acids | 443 aa |
| Exons | 28 |
| Pathways | MAPK, PI3K |
| UniProt ID | [Q9H6X7](https://www.uniprot.org/uniprot/Q9H6X7) |
| Ensembl ID | ENSG00000167792 |
| OMIM | 614518 |
| GeneCards | WDR81 |
| Human Protein Atlas | WDR81 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | AMPD2, CLCN7, GNAI3, GNPTG, JIP4, TMEM55B |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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