| Gene Symbol | STMN2PROTEIN |
| Full Name | Stathmin-2 |
| Protein Type | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| UniProt ID | Search UniProt |
| GeneCards | STMN2PROTEIN |
| Human Protein Atlas | STMN2PROTEIN |
| Stathmin-like domain (SLD) | The C-terminal region binds directly to α/β-tubulin heterodimers, preventing microtubule polymerization. This domain is highly conserved across the stathmin family. |
| C-terminal tail | Mediates protein-protein interactions and subcellular localization. |
| Axonal growth during development | High STMN2 expression promotes axonal extension by creating a permissive microtubule environment in growth cones. |
| Neuronal plasticity | Regulates microtubule dynamics in dendritic spines and presynaptic terminals, affecting synaptic plasticity. |
| Nerve injury response | Dramatically upregulated after peripheral nerve injury, promoting axonal regeneration<sup>[6]</sup>. |
| Signal transduction | Acts as a downstream effector of multiple neuronal signaling pathways. |
| Developing nervous system | High expression during embryonic and postnatal development |
| Adult brain | Moderate expression in cortical neurons, hippocampal pyramidal cells, and motor neurons |
| Associated Diseases | ALS, frontotemporal dementia, neurodegeneration |
| Interactions | Actin, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ATP, AXON REGENERATION |
| SciDEX Hypotheses | STMN2 Restoration as a Prerequisite for Axon Growt |
| KG Connections | 116 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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