| Gene Symbol | BBC3 |
| Full Name | BCL2 Binding Component 3 (PUMA) |
| Aliases | PUMAPROTEIN |
| Chromosome | 19q13.32 |
| Function | is a potent pro-apoptotic BH3-only protein of the BCL-2 family. |
| Molecular Weight | 20.2 kDa |
| Amino Acids | 193 aa |
| Pathways | Apoptosis, Er Stress, Ferroptosis, Unfolded Protein Response |
| Ensembl ID | ENSG00000105327 |
| GeneCards | BBC3 |
| Human Protein Atlas | BBC3 |
| BH3 domain | The essential pro-apoptotic domain (amino acids 93-120) that mediates interaction with anti-apoptotic Bcl-2 proteins |
| p53 binding sites | Two p53 response elements in the PUMA promoter that drive transcriptional activation |
| Mitochondrial targeting domain | Enables localization to mitochondria where PUMA exerts its pro-apoptotic effects |
| Direct activation | PUMA can directly activate Bax/Bak to induce mitochondrial outer membrane permeabilization (MOMP) |
| Associated Diseases | Als, Cancer, Inflammation, Lymphoma, Ms, Neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | AIF, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS |
| KG Connections | 253 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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