protein 557 words KG: PARK7
Contents

PARK7 Protein (DJ-1)

🔬 Protein Info
Gene SymbolPARK7
Full NamePARK7 (DJ-1)
AliasesPage for PARK7 Gene
Chromosome1p36.23
Protein TypeProtein
FunctionDJ-1 has multiple cellular functions
Primary ExpressionHigh in brain (substantia nigra), testis, kidney
Subcellular LocalizationCytoplasm, nucleus, mitochondria
Molecular Weight~20 kDa (189 amino acids)
Amino Acids189 aa
PathwaysAlpha-Synuclein, Autophagy, Epigenetic, Er Stress, Inflammasome
UniProt IDQ99497
GeneCardsPARK7
Human Protein AtlasPARK7
Protein NamePARK7/DJ-1 - Parkinsonism Associated Deglycase
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsACETYL-COA, AD, AGING, AKT, Alpha-Synuclein, ALS
KG Connections608 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (22)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
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Related Analyses (14)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

PARK7 associated_with neurodegeneration
PARK7 regulates SOD1
SOD1 regulates PARK7
PARK7 associated_with SOD1
PARK7 associated_with TAU
LRRK2 associated_with PARK7
PARK7 co_discussed SOD1
PARK7 co_discussed TAU
LRRK2 co_discussed PARK7
PARK7 co_discussed PINK1

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