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protein 1,442 words KG: NRF2PROTEIN
Contents

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)

🔬 Protein Info
Gene SymbolNRF2PROTEIN
Protein TypeTranscription Factor
Functionis a 605-amino acid transcription factor belonging to the CNC-bZIP family (Cap'n'Collar, alongside Nrf1, Nrf3, Bach1, Bach2).
Subcellular Localization</b></td><td>Cytoplasm (basal); nucleus (active)</td></tr>
Amino Acids605 aa
GeneCardsNRF2PROTEIN
Human Protein AtlasNRF2PROTEIN
Associated Diseasesaging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds4-octyl itaconate, 4OI, ALGERNON2, Alpha-Tocopherol, Artesunate, ATORVASTATIN
InteractionsABCG2, ACETYLCHOLINE, ACHE, ACOD1, ACSL4, Actin
KG Connections3445 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (11)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62Digital Twin-Guided Metabolic Reprogramming
Score: 0.55Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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