protein 1,671 words KG: NEFLPROTEIN
Contents

Neurofilament Light Chain Protein

🔬 Protein Info
Gene SymbolNEFLPROTEIN
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization| Neuronal axon (cytoskeleton) |- \! Protein Family | Type IV intermediate filam
Amino Acids543 aa
GeneCardsNEFLPROTEIN
Human Protein AtlasNEFLPROTEIN
Associated DiseasesAlzheimers_disease
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, BCL2, BNIP3L, C9ORF72, CNR1
SciDEX HypothesesPlasma NfL Elevation Secondary to BBB-Associated T
Plasma NfL Elevation Secondary to BBB-Associated T
KG Connections197 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (71)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
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Related Analyses (24)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (17)

ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Axonal Transport Dysfunction Validation in Parkinson's Disea
clinical · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40

See Also (15)

China Neurodegeneration Epidemiology
disease · Pages share 68 hypotheses
Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 68 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 68 hypotheses
Swedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 68 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 68 hypotheses

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