| Gene Symbol | MTOR |
| Full Name | Mechanistic Target of Rapamycin |
| Chromosome | 1p36.22 |
| Protein Type | Serine/Threonine Kinase |
| Target Class | Kinase |
| Function | mTOR is a central kinase integrating nutritional, growth factor, and energy signals |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: APOE-Dependent Autophagy Restoration |
| Druggability | Low (0.32) |
| Clinical Stage | Phase I |
| Molecular Weight | ~289 kDa |
| Amino Acids | 2549 amino acids |
| Pathways | autophagy-lysosome pathway, lysosomal biogenesis |
| UniProt ID | P42345 |
| NCBI Gene ID | 2475 |
| Ensembl ID | ENSG00000164362 |
| OMIM | 601231 |
| GeneCards | MTOR |
| Human Protein Atlas | MTOR |
| Associated Diseases | AD, ADH, Aging, Als, Alzheimer |
| Known Drugs/Compounds | alpelisib, Amino Acids, Arsenic trioxide, baicalein, Baicalein, Bnt162B2 |
| Interactions | 4EBP1, 6-OHDA, ABCA1, ABCG1, ABCG2, ACAT1 |
| SciDEX Target | View Target Profile (2 clinical trials) |
| SciDEX Hypotheses | APOE-Dependent Autophagy Restoration Chronic mTORC1-ULK1 signaling blocks autophagy ini Metabolic Checkpoint Reprogramming via TREM2-mTOR |
| KG Connections | 5900 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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