| Gene Symbol | ent-gene-7b80a607 |
| mTOR | Catalytic kinase subunit (shared with mTORC1) |
| PRAS40 | Inhibitory subunit that blocks substrate access when not phosphorylated |
| DEPTOR | Inhibitory subunit (shared with mTORC1) |
| Lipid synthesis | Activates SREBP transcription factors to promote fatty acid and cholesterol synthesis |
| Nucleotide synthesis | Promotes pyrimidine biosynthesis via S6K1-CAD axis |
| Mitochondrial biogenesis | Regulates PGC-1α activity through multiple pathways including YY1-mediated transcription |
| mSIN1 | Subunit-binding subunit that senses PI3K signaling strength |
| Protor-1/2 | Regulatory subunit with uncertain function |
| mLST8 | Stabilizes kinase domain (shared with mTORC1) |
| Cell survival | Phosphorylates Akt/PKB at Ser473 for full activation—this phosphorylation is critical for downstream survival signaling |
| Cytoskeletal remodeling | Regulates actin dynamics via PKCα and Rho GTPases |
| Neuronal morphology | Mediates neurite outgrowth and dendritic arborization during development and regeneration |
| Metabolic regulation | Modulates glucose and lipid metabolism through Akt-dependent pathways |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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