protein 1,312 words KG: MBD1PROTEIN
Contents

MBD1 Protein — Methyl-CpG Binding Domain Protein 1

🔬 Protein Info
Gene SymbolMBD1
Full NameMethyl-CpG Binding Domain Protein 1
Chromosome18q21.1
Protein FamilyMBD (Methyl-CpG Binding Domain)
Functionis a critical epigenetic regulator that binds to methylated CpG dinucleotides in DNA and recruits chromatin remodeling complexes to silence gene expression.
Molecular Weight66 kDa
Amino Acids605 aa
Exons17
PathwaysDna Methylation, epigenetic regulation
UniProt IDQ9P273
NCBI Gene ID4153
Ensembl IDENSG00000141644
OMIM156311
GeneCardsMBD1
Human Protein AtlasMBD1
Associated Diseasesneurodegeneration
InteractionsC-FOS, EZH2, FOS, SDHB, VHL
KG Connections10 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (13)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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