| Gene Symbol | LIPA |
| Aliases | LIPAPROTEIN |
| Protein Type | Enzyme |
| Function | LIPA encodes lysosomal acid lipase (LIPA or LAL), a crucial enzyme that hydrolyzes cholesteryl esters and triglycerides in the lysosome. |
| Primary Expression | neurons, astrocytes, and microglia, with particular importance in lipid-rich region |
| Subcellular Localization | Lysosome |
| Molecular Weight | ~43 kDa (374 amino acids) |
| Pathways | Cholesterol, Alpha-Synuclein, Lipid Metabolism, Phagocytosis, Apoptosis |
| UniProt ID | P38571 |
| Ensembl ID | ENSG00000107796 |
| GeneCards | LIPA |
| Human Protein Atlas | LIPA |
| Protein Name | LIPA - Lysosomal Acid Lipase |
| Gene | LIPA |
| Protein Class | Hydrolase, Lysosomal enzyme |
| Associated Diseases | ALS, Alzheimer |
| Interactions | ABCA1, Actin, AGING, ALPHA-SYNUCLEIN, APOE, ATG |
| KG Connections | 167 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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