| Gene Symbol | HSP90 |
| Full Name | Heat Shock Protein 90 |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | </td><td>Cytosol, nucleus (constitutive), stress-inducible</td></tr> |
| Molecular Weight | 90 kDa |
| Amino Acids | 220 aa |
| Pathways | Apoptosis, Autophagy, Chaperone, Oxidative Stress |
| GeneCards | HSP90 |
| Human Protein Atlas | HSP90 |
| EEVD motif | Conserved C-terminal sequence for co-chaperone binding |
| Client protein maturation | Helps fold signaling proteins, steroid receptors, kinases |
| Complex assembly | Facilitates formation of multi-protein complexes |
| Quality control | Targets misfolded proteins for degradation |
| Stress protection | Rapidly upregulated under various stresses |
| Associated Diseases | ALS, Alzheimer's disease, Depression, HUNTINGTON, HUNTINGTON'S |
| Known Drugs/Compounds | 17-AAG |
| Interactions | AD, AGING, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE |
| KG Connections | 606 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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