| Gene Symbol | HNRPU |
| Full Name | HNRPU Protein |
| Aliases | Heterogeneous Nuclear Ribonucleoprotein U |
| Chromosome | 1q44 |
| Function | HNRNP U (hnRNP U) encodes a nuclear matrix protein with multiple functional domains including an acidic region, glycine-rich domains, and an RNA-binding domain. |
| Subcellular Localization | </strong></td><td>Nucleus (nuclear matrix)</td></tr> |
| Molecular Weight | 120 kDa |
| Amino Acids | 806 aa |
| UniProt ID | [Q00839](https://www.uniprot.org/uniprot/Q00839) |
| Ensembl ID | ENSG00000197181 |
| OMIM | 604365 |
| GeneCards | HNRPU |
| Human Protein Atlas | HNRPU |
| N-terminal acidic domain (aa 1-90) | Mediates protein-protein interactions and chromatin binding |
| Proline-rich region (aa 100-250) | Involved in transcriptional regulation |
| Associated Diseases | ALS |
| Interactions | Actin, AND, DNA, HNRNPA2B1, NUCLEOLIN, Proteins |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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