| Gene Symbol | DIABLO |
| Full Name | Direct IAP-Binding Protein with Low pI |
| Aliases | Second Mitochondria-Derived Activator of Caspases (SMAC) |
| Chromosome | 12q24.31 |
| Function | is a mitochondrial protein that plays a critical role in regulating apoptosis through its interactions with Inhibitor of Apoptosis Proteins (IAPs). |
| Primary Expression | most human tissues, with highest expression in testis, heart, brain, and skeletal muscle |
| Molecular Weight | 25 kDa |
| Amino Acids | 239 aa |
| Exons | 6 |
| Pathways | Apoptosis |
| UniProt ID | [Q9NR28](https://www.uniprot.org/uniprot/Q9NR28) |
| Ensembl ID | ENSG00000140297 |
| OMIM | 604476 |
| GeneCards | DIABLO |
| Human Protein Atlas | DIABLO |
| Associated Diseases | neurodegeneration |
| Interactions | APOPTOSIS, AUTOPHAGY, CYLD, FADD, HTRA2, LC3 |
| KG Connections | 52 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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