| Gene Symbol | C3 |
| Full Name | C3 — Complement Component 3 |
| Aliases | Complement Component 3 |
| Chromosome | 19p13.3 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | Small molecule inhibitor of complement activation or convertase activity |
| Mechanism of Action | Small molecule inhibitor of complement activation or convertase activity |
| Subcellular Localization | </strong></td><td>Secreted, plasma, cytoplasm</td></tr> |
| Druggability | Medium (0.50) |
| Clinical Stage | Approved |
| Molecular Weight | 110 kDa |
| Amino Acids | 663 aa |
| Exons | 41 |
| Pathways | C1q / complement-mediated synapse elimination, Complement System Activation, Complement-Mediated Microglial Engulfment, Synaptic Pruning |
| UniProt ID | P01024 |
| NCBI Gene ID | 735 |
| GeneCards | C3 |
| Human Protein Atlas | C3 |
| Associated Diseases | Alzheimer's disease, diabetes, Dopaminergic Neuron Loss, Frontotemporal Dementia |
| Known Drugs/Compounds | CR2_CRRY, curcumin, dimethyl fumarate, resveratrol |
| Interactions | ADIPOQ, ALPHA_SYN, AMYLOID, AMYLOID_BETA, APOA1, APOE |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 585 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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