| Gene Symbol | BTK |
| Aliases | BTKPROTEIN |
| Function | ### B Cell Receptor Signaling |
| Subcellular Localization | | | TH domain | Proline-rich | Proline-rich motifs for SH3 interactions | | SH3 |
| Molecular Weight | 76 kDa |
| Amino Acids | 659 aa |
| Pathways | PI3K, NF-κB, MAPK |
| GeneCards | BTK |
| Human Protein Atlas | BTK |
| PLCγ2 | Calcium signaling, NFAT activation |
| PI3K/AKT | Cell survival signaling |
| [NF-κB](/entities/nf-kb) | Transcriptional activation |
| MAPK/ERK | Cell proliferation |
| Macrophages | Inflammatory cytokine production |
| [Neurons](/entities/neurons) | Developmental roles |
| Associated Diseases | ALS, Alzheimer, neurodegeneration, neuroinflammation |
| Known Drugs/Compounds | ZANUBRUTINIB |
| Interactions | AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOPTOSIS |
| KG Connections | 127 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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