protein 3,061 words KG: BECLIN1PROTEIN
Contents

Beclin-1 Protein

🔬 Protein Info
Gene SymbolBECLIN1
Full NameBECN1
AliasesBECLIN1PROTEIN
Chromosome17q21
Protein TypeGene
Functionis a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis
PathwaysApoptosis, Autophagy, Mtor, Oxidative Stress
GeneCardsBECLIN1
Human Protein AtlasBECLIN1
Associated DiseasesAls, Alzheimer, Cancer, Colorectal Cancer, Glioblastoma, Inflammation
InteractionsABCA1, ACTB, ADSL, AKT, AKT1, ALZHEIMER
KG Connections618 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (11)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.88
Circadian Clock-Autophagy Synchronization
Score: 0.76
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (2)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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