| Gene Symbol | AR |
| Aliases | ARPROTEIN |
| Chromosome | Xq12 |
| Protein Type | Gene |
| Function | encodes a nuclear receptor protein that binds testosterone and dihydrotestosterone, mediating the effects of androgen hormones in target tissues. |
| Primary Expression | brain regions including: - Spinal cord: Motor neurons, including those innervating skeletal muscle - Hypothalamus: Regulatory centers for hor |
| Subcellular Localization | </strong></td><td>Cytoplasm (unbound) → Nucleus (bound)</td></tr> |
| Molecular Weight | 110 kDa |
| Amino Acids | 919 aa |
| GeneCards | AR |
| Human Protein Atlas | AR |
| Activation Function 1 (AF-1) | Transactivation region mediating transcriptional activation |
| Polyglutamine (CAG) tract | Normal length 10-36 repeats; expansion causes SBMA |
| PSA (KLK3) | Prostate-specific antigen |
| TMPRSS2 | Transmembrane protease |
| Associated Diseases | Aromatase Inhibitor Resistance, cancer |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACTB, AKT, ALS, AMBRA1, AMPK, APP |
| SciDEX Hypotheses | Testosterone-Derived DHT Amplifies Microglial Andr |
| KG Connections | 178 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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