| Gene Symbol | AIM2 |
| Aliases | AIM2PROTEIN |
| Protein Family | AIM2-like receptor (ALR) |
| Function | AIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome. |
| Subcellular Localization | Cytoplasm |
| Molecular Weight | 39 kDa |
| Amino Acids | 200 aa |
| Pathways | Apoptosis, Autophagy, Cholesterol, Ferroptosis, Immune Response |
| UniProt ID | Q9WZE6 |
| GeneCards | AIM2 |
| Human Protein Atlas | AIM2 |
| Interaction with ASC | The PYD recruits the adaptor protein ASC (PYCARD) through PYD-PYD interactions |
| Oligomerization | AIM2 PYD mediates the formation of the inflammasome complex |
| Signal integration | Serves as a platform for integrating upstream activation signals |
| Oligosaccharide-binding (OB) folds | Two OB folds form a DNA-binding pocket |
| Associated Diseases | Als, Atherosclerosis, Cancer, Dementia, Infection |
| Interactions | ACTB, Actin, ALZHEIMER, AMPK, AND, APOPTOSIS |
| KG Connections | 410 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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