Contents

TREM2-SYK Signaling Cascade

🔬 Protein Info

Gene Symbol	TREM2
Full Name	SYK Signaling Cascade
Aliases	Triggering Receptor Expressed on Myeloid cells 2, TREM-2
Chromosome	6p21.1
Protein Type	Receptor
Target Class	Receptor
Function	Lipid sensing; Debris clearance; Microglial activation
Mechanism of Action	Agonist antibodies that enhance TREM2 signaling to promote microglial function
Primary Expression	Microglia, Cerebral cortex, Hippocampus
Druggability	Low (0.42)
Clinical Stage	Phase II
Molecular Weight	35 kDa
Amino Acids	231 aa
Exons	5
Pathways	Innate immunity, Phagocytosis, DAP12-SYK signaling
UniProt ID	Q9NZC2
NCBI Gene ID	54209
Ensembl ID	ENSG00000095970
OMIM	605086
GeneCards	TREM2
Human Protein Atlas	TREM2
Associated Diseases	1-bromopropane neurotoxicity, AD risk, aging, Als
Known Drugs/Compounds	aducanumab, AL002, Al002C, AL002C, amyloid deposits, anti-TREM2 antibodies
Interactions	A2M, AB, ABCA1, ABCA7, ABCG1, ABETA
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	TREM2-Dependent Astrocyte-Microglia Cross-talk in TREM2-Dependent Microglial Senescence Transition TREM2-Mediated Astrocyte-Microglia Cross-Talk in N (+55 more)
KG Connections	3576 knowledge graph edges
Databases	GeneCards HPA STRING

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