Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AL002C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AL002C |
| Key Genes/Proteins | AMYLOID_PLAQUES, TREM2 |
| Related Diseases | NEURITE_DYSTROPHY |
| Related Pathways | INFLAMMATORY_RESPONSE, PROLIFERATION |
graph TD
AL002C[AL002C]
AL002C -->|activates| Microglia_Proliferation[Microglia Proliferation]
AL002C -->|activates| microglia_proliferation[microglia proliferation]
AL002C -->|activates| TREM2[TREM2]
AL002C -->|inhibits| Microglial_Inflammatory_Respon[Microglial Inflammatory Response]
AL002C -->|treats| Alzheimer_S_Disease[Alzheimer'S Disease]
AL002C -->|treats| Alzheimer_s_Disease[Alzheimer's Disease]
AL002C -->|inhibits| filamentous_plaques[filamentous plaques]
AL002C -->|inhibits| neurite_dystrophy[neurite dystrophy]| Target | Relation | Type | Str |
|---|---|---|---|
| microglia proliferation | activates | phenotype | 0.92 |
| Microglia Proliferation | promotes | process | 0.92 |
| Microglia Proliferation | activates | process | 0.92 |
| TREM2 | activates | protein | 0.90 |
| TREM2 | activates | protein | 0.90 |
| Neurite Dystrophy | associated_with | phenotype | 0.90 |
| Amyloid Plaques | associated_with | phenotype | 0.90 |
| Filamentous Plaques | associated_with | phenotype | 0.88 |
| Microglial Inflammatory Response | inhibits | process | 0.87 |
| Neurite Dystrophy | associated_with | phenotype | 0.85 |
| Alzheimer'S Disease | treats | disease | 0.85 |
| Alzheimer's Disease | treats | disease | 0.82 |
| filamentous plaques | inhibits | phenotype | 0.80 |
| neurite dystrophy | inhibits | phenotype | 0.80 |
| NEURITE_DYSTROPHY | inhibits | phenotype | 0.64 |
| AMYLOID_PLAQUES | inhibits | protein | 0.64 |
| PROLIFERATION | activates | pathway | 0.64 |
| INFLAMMATORY_RESPONSE | inhibits | pathway | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning AL002C in their description or question text
No additional research found