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mechanism 2,557 words KG: ent-gene-58ffe46a
Contents

SYK Kinase in Microglial Activation and Alzheimer's Disease

🔬 Protein Info
Gene Symbolent-gene-58ffe46a
Activating phosphorylationTyr352 in the interdomain and Tyr323 in the linker region promote kinase activity
Inhibitory phosphorylationTyr317 and Tyr525/526 in the kinase domain suppress catalytic activity
AutophosphorylationSYK undergoes autophosphorylation following receptor engagement
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (41)

Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67Microbial Inflammasome Priming Prevention
Score: 0.65Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79APOE-TREM2 Interaction Modulation
Score: 0.74Orexin-Microglia Modulation Therapy
Score: 0.71Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63Epigenetic Memory Erasure via TET2 Activation
Score: 0.74Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70SASP-Mediated Complement Cascade Amplification
Score: 0.70Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
← Prevpg 2/3Next →

Related Analyses (30)

Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.51

See Also (15)

GFAP in Alzheimer's Disease
biomarker · Pages share 18 hypothesesOlfactory Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesAlzheimer's Disease Biomarkers
biomarker · Pages share 18 hypothesesASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesNPTX1 and NPTXR CSF Markers Predict Alzheimer's Disease
biomarker · Pages share 21 hypotheses

Knowledge Graph (11 edges)

h-5d753df0 targets ent-gene-58ffe46a
ent-gene-58ffe46a targeted_by h-5d753df0
h-6358a464ac targets ent-gene-58ffe46a
ent-gene-58ffe46a targeted_by h-6358a464ac
36257314 critically regulates ent-gene-58ffe46a
h-15a8468c targets ent-gene-58ffe46a
ent-gene-58ffe46a targeted_by h-15a8468c
ent-gene-58ffe46a data_in benchmark_ot_ad_answer_key:SYK
benchmark_ot_ad_answer_key:SYK data_in ent-gene-58ffe46a
h-9f5ce0a588 targets ent-gene-58ffe46a

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