mechanism 1,164 words KG: ent-gene-7ab18253
Contents

EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-7ab18253
Chromosome7q34
Functiontyrosine kinase of the Eph family
Forward signalingActivation of intracellular cascades upon ephrin ligand binding
Reverse signalingTransduction of signals into ephrin-expressing cells
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (71)

Glial Glycocalyx Remodeling Therapy
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
Netrin-1 Gradient Restoration
Score: 0.59
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.29
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
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Related Analyses (30)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (11)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
CD2AP downregulation in brain endothelial cells - memory fun
validation · proposed · Score: 0.90
Cerebrovascular function analysis in CD2AP mutant mice
validation · proposed · Score: 0.90
CD2AP expression and cognitive decline in AD patients
exploratory · proposed · Score: 0.80
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

Knowledge Graph (4 edges)

ent-gene-7ab18253 participates_in_pathway R-HSA-3928663
ent-gene-7ab18253 participates_in_pathway R-HSA-3928665
ent-gene-7ab18253 participates_in_pathway R-HSA-2682334
ent-gene-7ab18253 participates_in_pathway R-HSA-2892247

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