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mechanism 1,164 words KG: ent-gene-7ab18253
Contents

EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-7ab18253
Chromosome7q34
Functiontyrosine kinase of the Eph family
Forward signalingActivation of intracellular cascades upon ephrin ligand binding
Reverse signalingTransduction of signals into ephrin-expressing cells
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (71)

Purinergic Signaling Polarization Control
Score: 0.71Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Orexin-Microglia Modulation Therapy
Score: 0.71Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Mechanosensitive Ion Channel Reprogramming
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Ocular Immune Privilege Extension
Score: 0.69Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
← Prevpg 2/4Next →

Related Analyses (30)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (11)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40CD2AP downregulation in brain endothelial cells - memory fun
validation · proposed · Score: 0.90Cerebrovascular function analysis in CD2AP mutant mice
validation · proposed · Score: 0.90CD2AP expression and cognitive decline in AD patients
exploratory · proposed · Score: 0.80Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

Knowledge Graph (4 edges)

ent-gene-7ab18253 participates_in_pathway R-HSA-3928663
ent-gene-7ab18253 participates_in_pathway R-HSA-3928665
ent-gene-7ab18253 participates_in_pathway R-HSA-2682334
ent-gene-7ab18253 participates_in_pathway R-HSA-2892247

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