mechanism 1,164 words KG: ent-gene-7ab18253
Contents

EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-7ab18253
Chromosome7q34
Functiontyrosine kinase of the Eph family
Forward signalingActivation of intracellular cascades upon ephrin ligand binding
Reverse signalingTransduction of signals into ephrin-expressing cells
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (71)

APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
APOE Isoform Conversion Therapy
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.54
...
Score: 0.68
APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
← Prevpg 4/4

Related Analyses (30)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (11)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
CD2AP downregulation in brain endothelial cells - memory fun
validation · proposed · Score: 0.90
Cerebrovascular function analysis in CD2AP mutant mice
validation · proposed · Score: 0.90
CD2AP expression and cognitive decline in AD patients
exploratory · proposed · Score: 0.80
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

Knowledge Graph (4 edges)

ent-gene-7ab18253 participates_in_pathway R-HSA-3928663
ent-gene-7ab18253 participates_in_pathway R-HSA-3928665
ent-gene-7ab18253 participates_in_pathway R-HSA-2682334
ent-gene-7ab18253 participates_in_pathway R-HSA-2892247

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