| Gene Symbol | Septin 2 |
| Aliases | SEPTIN2 |
| Chromosome | 2q37.3 |
| Protein Family | Septin GTPases |
| Function | is a founding member of the septin family of GTP-binding proteins that play essential roles in cytoskeletal organization, membrane dynamics, and cellular signaling. |
| Molecular Weight | 41.5 kDa |
| Amino Acids | 361 aa |
| UniProt ID | Q15020 |
| NCBI Gene ID | 4735 |
| OMIM | 601680 |
| GTPase activity | SEPTIN2 binds GTP and undergoes conformational changes upon nucleotide hydrolysis, enabling it to act as a molecular switch |
| Scaffold formation | Septin filaments serve as platforms for protein kinase localization and signaling complex assembly |
| Membrane organization | Septins associate with plasma membrane microdomains and organelle membranes |
| Cytoskeletal interaction | SEPTIN2 bridges actin filaments and microtubules, influencing cytoskeletal dynamics |
| Autophagy regulation | Septins participate in autophagosome formation and cargo selective autophagy[@tth2016] |
| Associated Diseases | neurodegeneration |
| Interactions | INFLAMMATION, RAC1 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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