gene 1,646 words KG: SALL1
Contents

SALL1 Gene

🧬 Gene Info
Gene SymbolSALL1
AliasesSal-like protein 1
Chromosome16
Protein TypeTranscription Factor
Functionis a zinc-finger transcription factor that plays critical roles in embryonic development and cellular differentiation.
Primary Expressionall microglial subpopulations - Maintained in adult microglia throughout life - Not expressed in neurons, astrocytes, or oligodendrocytes - Specific t
Amino Acids322 aa
ExonsMultiple exons encoding the full-length protein
GeneCardsSALL1
Human Protein AtlasSALL1
Band16q12.1
Genomic coordinatesApproximately 51,180,000-51,250,000 (GRCh38)
Gene lengthApproximately 70 kb
Associated DiseasesAlzheimer's disease pathogenesis:
InteractionsAPOE, CX3CR1, HEXB, P2RY12, TMEM119, TREM2
KG Connections25 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (14)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Microglial Purinergic Reprogramming
Score: 0.70
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (3)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (3)

Neurodegeneration
disease · KG edge: implicated_in
PAX2 Gene
gene · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: expressed_in

Knowledge Graph (12 edges)

PAX2 associated_with SALL1
SALL1 associated_with PAX2
SALL1 expressed_in Progenitor Cell
SALL1 expressed_in Podocyte
HEXB activates SALL1
SALL1 activates TMEM119
APOE activates SALL1
CX3CR1 activates SALL1
P2RY12 activates SALL1
SALL1 activates TREM2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)