| Gene Symbol | ROBO2 |
| Chromosome | 3p12.3 |
| Protein Type | Gene |
| Function | ROBO2 (Roundabout Guidance Receptor 2) is a transmembrane receptor for Slit proteins (Slit1, Slit2, Slit3) that plays critical roles in axon guidance, neuronal migration, and neural crest cell migrati |
| Primary Expression | developing midbrain dopaminergic neurons and regulates their proper migration and axonal projection [@jaworski2019] |
| Pathways | MAPK, PI3K |
| GeneCards | ROBO2 |
| Human Protein Atlas | ROBO2 |
| Extracellular Domain | 5 immunoglobulin (Ig) domains followed by 3 fibronectin type III (FNIII) repeats, mediating ligand binding |
| Transmembrane Domain | Single pass membrane-spanning helix |
| Cytoplasmic Domain | Contains conserved motifs including CC0, CC1, and CC2 (conserved cytoplasmic motifs) that recruit downstream signaling proteins |
| Rho GTPase-activating proteins (GAPs) | Regulate RhoA, Rac1, and Cdc42 activity |
| Disabled-1 (Dab1) | Adapter protein involved in cytoskeletal reorganization |
| RhoGEFs | Activate specific Rho GTPases for cytoskeletal remodeling |
| Midline repulsion | Prevents inappropriate crossing of the midline in the central nervous system |
| Associated Diseases | Schizophrenia |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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