gene 586 words KG: PARP3
Contents

PARP3 Gene

🧬 Gene Info
Gene SymbolPARP3
Full NamePoly(ADP-Ribose) Polymerase 3
Chromosome3p21.2
Protein FamilyPARP family
FunctionPARP3 is primarily involved in:
Primary ExpressionUbiquitous
Molecular Weight60 kDa
Amino Acids583 aa
UniProt IDQ9Y5F4
NCBI Gene ID10039
Ensembl IDENSG00000050767
GeneCardsPARP3
Human Protein AtlasPARP3
Associated Diseasesneurodegeneration
InteractionsAGING, DNA, TNKS
KG Connections17 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
PARP1 Inhibition Therapy
Score: 0.74
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · completed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
PARP1 Gene
gene · KG edge: associated_with
PARP2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PARP3 associated_with TREM2
PARP3 associated_with OxPC
PARP2 associated_with PARP3
PARP1 associated_with PARP3
PARP3 inhibits TNKS
PARP3 inhibits AGING
PARP3 inhibits DNA
PARP3 inhibits Cardiovascular
PARP3 inhibits Diabetes
PARP3 inhibits Aging

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