| Gene Symbol | PABPN1 |
| Chromosome | 14q11.2 |
| Function | It interacts with the cleavage and polyadenylation specificity factor (CPSF) complex to ensure proper 3'-end processing of pre-mRNA [1]. |
| Molecular Weight | 33 kDa |
| Amino Acids | 306 aa |
| Exons | 17 |
| Pathways | Proteasome, Ubiquitin-Proteasome |
| Ensembl ID | ENSG00000122591 |
| GeneCards | PABPN1 |
| Human Protein Atlas | PABPN1 |
| mRNA Export | The protein facilitates mRNA export from the nucleus to the cytoplasm by interacting with export receptors. This function is crucial for delivering processed mRNAs to ribosomes for translation [2]. |
| Translation Regulation | PABPN1 modulates translation efficiency through its interaction with translation initiation factors. It can either enhance or repress translation depending on the mRNA context and cellular state. |
| mRNA Stability | By protecting poly(A) tails from deadenylation, PABPN1 contributes to mRNA stability and half-life. This function is particularly important for long-lived mRNAs involved in cellular homeostasis. |
| RNA Recognition Motif (RRM) | Located at the N-terminus, mediates RNA binding |
| Glycine-rich domain | Involved in protein-protein interactions |
| Associated Diseases | Als |
| Interactions | GAIN, HSP70, TDP43 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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