| Gene Symbol | KDM5B |
| Full Name | Lysine Demethylase 5B |
| Chromosome | 1q32.1 |
| Function | encodes a Jumonji C (JmjC) domain-containing histone demethylase that specifically removes di- and trimethyl marks from histone H3 lysine 4 (H3K4me2/3). |
| Amino Acids | 1544 aa |
| Pathways | Angiogenesis, Epigenetic |
| UniProt ID | [Q9UGL1](https://www.uniprot.org/uniprot/Q9UGL1) |
| Ensembl ID | ENSG00000117139 |
| GeneCards | KDM5B |
| Human Protein Atlas | KDM5B |
| JmjN + JmjC domains | Together form the catalytic core; JmjC contains the Fe(II) and α-ketoglutarate (2-OG) binding sites required for oxidative demethylation |
| ARID domain | An AT-rich interaction domain that binds DNA, providing sequence-specific targeting to CCGCCC motifs enriched at CpG island promoters |
| PHD fingers (3x) | PHD1 reads unmethylated H3K4 (product recognition), PHD2 and PHD3 bind H3K4me3 (substrate recognition), enabling allosteric activation upon engagement with trimethylated substrates |
| C5HC2 zinc finger | Mediates protein-protein interactions for complex formation |
| Promoter H3K4me3 removal | KDM5B demethylates H3K4me3 at promoters of non-neural genes during neuronal differentiation, enabling silencing of progenitor programs as neurons mature |
| Associated Diseases | neurodegeneration |
| Interactions | AND, NPM1, RNA |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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