gene 1,855 words KG: IDUA
Contents

IDUA Gene

🧬 Gene Info
Gene SymbolIDUA
Full NameAlpha-L-iduronidase
Chromosome4p16.3
Protein TypeHydrolase
FunctionHeparan sulfate degradation: IDUA removes iduronic acid residues
Molecular Weight76 kDa
Amino Acids653 aa
UniProt IDP35475
NCBI Gene ID3419
Ensembl IDENSG00000127418
OMIM609014
GeneCardsIDUA
Human Protein AtlasIDUA
Acid-base catalysisResidues in the active site facilitate hydrolysis
Substrate specificityRecognizes the non-reducing end of heparan sulfate and dermatan sulfate
Associated Diseasesneurodegeneration
InteractionsTAU
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (170)

Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
← Prevpg 4/9Next →

Related Analyses (30)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (13)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: therapeutic_target
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: therapeutic_target
Genes
index · KG edge: associated_with
ACE Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

ACE therapeutic_target IDUA
TREM2 therapeutic_target IDUA
PILRA therapeutic_target IDUA
IDUA activates TAU
IDUA therapeutic_target GRN
CTSD co_discussed IDUA
IDUA co_discussed INPP5D
IDUA co_discussed NLRP1
IDUA co_discussed SMPD1
INPP5D associated_with IDUA

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