gene 1,014 words KG: HAPLN4
Contents

HAPLN4 Gene (Hyaluronan and Proteoglycan Link Protein 4)

🧬 Gene Info
Gene SymbolHAPLN4
Functionencodes a member of the hyaluronan and proteoglycan link protein (HAPLN) family.
Amino Acids402 aa
PathwaysMAPK pathway
Ensembl IDENSG00000166920
GeneCardsHAPLN4
Human Protein AtlasHAPLN4
HAPLN4 (BRAL1)brain-specific
N-terminal domainHyaluronan-binding region
Core proteinLink protein core
C-terminal domainProteoglycan-binding region
Signal peptideN-terminal targeting sequence (~20 aa)
Link moduleConserved hyaluronan-binding domain (~100 aa)
Core regionVariable length (~250 aa)
C-terminal regionProteoglycan interaction sites
Associated DiseasesAlzheimer's disease, Schizophrenia, Epilepsy
KG Connections8 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.95
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (8)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Extracellular Matrix and Perineuronal Nets in 4R-Tauopa
mechanism · KG edge: participates_in
Alpha-Synuclein Seeding Assays (RT-QuIC and PMCA)
biomarker · Pages share 3 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (8 edges)

HAPLN4 regulates GABAergic synapses
HAPLN4 component_of perineuronal nets
HAPLN4 participates_in extracellular matrix
HAPLN4 interacts_with MAPK pathway
HAPLN4 expressed_in Purkinje cells
HAPLN4 expressed_in Deep cerebellar nuclei neurons
HAPLN4 regulates Fast-signaling synapses
HAPLN4 participates_in Extracellular matrix

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