| Gene Symbol | BRD2 |
| Full Name | Bromodomain-Containing Protein 2 |
| Chromosome | 6p21.3 |
| Function | encodes a BET (Bromodomain and Extra-Terminal domain) family transcriptional regulator that reads acetylated histones and recruits transcriptional machinery to active chromatin. |
| UniProt ID | [P25440](https://www.uniprot.org/uniprot/P25440) |
| Ensembl ID | ENSG00000204256 |
| GeneCards | BRD2 |
| Human Protein Atlas | BRD2 |
| Bromodomain 1 (BD1) | Preferentially binds di-acetylated H4 (H4K5acK12ac), a mark enriched at gene promoters during active transcription |
| Bromodomain 2 (BD2) | Binds acetylated H4K5/K8/K12 with broader specificity, contributing to chromatin association during different transcriptional states |
| ET domain | Mediates protein-protein interactions with transcription factors, including recruitment of the Mediator complex and transcriptional elongation factors |
| SEED domain | BRD2-specific domain that interacts with E2F transcription factors, linking histone acetylation to cell cycle gene expression |
| Transcriptional coactivation | BRD2 bridges acetylated chromatin to the transcriptional machinery, facilitating expression of neural-specific genes including ion channels, neurotransmitter receptors, and synaptic proteins |
| Cell cycle regulation | BRD2 interacts with E2F1/E2F2 to drive expression of cyclins and CDKs required for neural progenitor proliferation; BRD2 heterozygous knockout mice show reduced neural tube cell proliferation |
| GABAergic neuron development | BRD2 is essential for specification and maturation of GABAergic interneurons. BRD2 haploinsufficiency reduces GABAergic neuron density, providing a direct mechanistic link to epilepsy |
| Associated Diseases | ALS |
| Interactions | BRD3, BRD4 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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