| Gene Symbol | BRD3 |
| Full Name | Bromodomain-Containing Protein 3 |
| Chromosome | 9q34.2 |
| Function | encodes a member of the BET (Bromodomain and Extra-Terminal domain) family of chromatin readers, alongside BRD2, BRD4, and BRDT. |
| Amino Acids | 726 aa |
| UniProt ID | [Q15059](https://www.uniprot.org/uniprot/Q15059) |
| Ensembl ID | ENSG00000169925 |
| GeneCards | BRD3 |
| Human Protein Atlas | BRD3 |
| Bromodomains BD1 and BD2 | Tandem bromodomains that recognize acetylated histones (particularly H4K5ac, H4K8ac, H4K12ac, and H3K14ac) and acetylated non-histone proteins |
| Extra-terminal (ET) domain | Mediates protein–protein interactions with transcriptional co-regulators including NSD3, JMJD6, CHD4, and components of the ATAC and SWI/SNF chromatin remodeling complexes |
| SEED motif | Phosphorylation-dependent regulatory region |
| C-terminal domain (CTD) | Unlike BRD4, BRD3 lacks the extended CTD that mediates P-TEFb recruitment, giving it distinct functional roles |
| Transcriptional regulation | BRD3 promotes transcription from acetylated chromatin but does not directly recruit P-TEFb (unlike BRD4), instead facilitating RNA polymerase II passage through acetylated nucleosomal templates |
| Hematopoietic transcription | BRD3 has a specialized role in GATA1-dependent erythroid gene expression, directly binding acetylated GATA1 to maintain erythroid transcriptional programs |
| Associated Diseases | ALS |
| Interactions | BRD2, BRD4 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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