| Gene Symbol | ATP5B |
| Chromosome | 12p13.33 |
| Protein Type | Gene |
| Function | is a central hallmark of neurodegenerative diseases, and ATP5B plays a critical role in this pathology. |
| Molecular Weight | 56 kDa |
| Amino Acids | 529 aa |
| Exons | 13 |
| GeneCards | ATP5B |
| Human Protein Atlas | ATP5B |
| N-terminal region | Mitochondrial targeting sequence (cleaved after import) |
| P-loop NTP-binding domain | Walker A motif (GXXXXGKT) for nucleotide binding |
| Central domain | Forms the interface between subunits during conformational changes |
| C-terminal domain | Contains the Walker B motif (hhhhDE) for ATP hydrolysis |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | resveratrol |
| Interactions | AMPK, ATP, CHOP, INSULIN RESISTANCE, MITOCHONDRIA, ROS |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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