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gene 2,267 words KG: apoe
Contents

APOE — Apolipoprotein E

🧬 Gene Info
Gene SymbolAPOE
Full NameApolipoprotein E
Chromosome19q13.32
Target ClassLigand
FunctionIt binds to the LDL receptor family to facilitate uptake of lipoprotein particles.
Mechanism of ActionProtein-protein interaction modulator or lipid metabolism enhancer
DruggabilityMedium (0.47)
Clinical StagePhase II
Molecular Weight34 kDa
PathwaysAmyloid, Autophagy, Blood-Brain Barrier, Brain Lipid Metabolism, Cholesterol
GeneCardsAPOE
Human Protein AtlasAPOE
Associated DiseasesAD, Age Of Onset, aging, alpha-synucleinopathies
Known Drugs/Compoundsatherogenic lipoproteins, Crispr, curcumin
InteractionsA2M, ABC7 transporter, ABCA1, abca2, ABCA2, ABCA7
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesPrime Editing Precision Correction of APOE4 to APO
Selective APOE4 Degradation via Proteolysis Target
Competitive APOE4 Domain Stabilization Peptides (+18 more)
KG Connections5209 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72

Related Analyses (30)

Lipid metabolism dysregulation and membrane integrity in Alz
neurodegeneration · completedTREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedWhat are the specific molecular determinants that govern tau
neurodegeneration · completedNeuroinflammation and microglial priming in early AD
neurodegeneration · completed

Related Experiments (30)

KEEPS Continuation: Long-term effects of menopausal hormone
clinical · proposed · Score: 0.95GWAS of plasma NfL in East Asian cohort
exploratory · proposed · Score: 0.95GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95Dairy intake and dementia risk in Malmö Diet and Cancer coho
clinical · proposed · Score: 0.95GWAS of plasma pTau181 in East Asian cohort
exploratory · proposed · Score: 0.95

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypothesesLX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypothesesUPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypothesesremternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (6 edges)

apoe data_in ad_genetic_risk_loci:APOE
ad_genetic_risk_loci:APOE data_in apoe
apoe data_in benchmark_ot_ad_answer_key:APOE
benchmark_ot_ad_answer_key:APOE data_in apoe
apoe implicated_in neurodegeneration
entities-microglia-in-neurodegeneration interacts_with apoe

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