disease 6,462 words KG: FTD
Contents

Frontotemporal Dementia (FTD)

Disease Info
Behavioral variant FTD (bvFTD)Progressive changes in personality, social conduct, and executive function, with early behavioral disinhibition, apathy, loss of empathy, and compulsive/ritualistic behaviors
Associated GenesACHE, AD, AKT, AMYLOID, APOE, APP, BDNF, C9orf72
KG Connections783 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (5)

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.82
C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD
Score: 0.72
Astrocyte-Neuron Metabolic Coupling Failure Precedes Neurode
Score: 0.69
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A
Score: 0.66
Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulat
Score: 0.62

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (9)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40
Frontal and Temporal Lobe Selective Vulnerability in FTD — M
validation · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40

Knowledge Graph (12 edges)

TAU associated_with FTD
TAU causes FTD
FTD inhibits MITOCHONDRIAL_PROTEINS
FTD inhibits BIOENERGETICS
FTD regulates TAU
TDP43 associated_with FTD
C9ORF72 causes FTD
VESICLE_TRAFFICKING associated_with FTD
GGGGCC_repeat causes FTD
FTD regulates MITOCHONDRIAL_PROTEINS

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